Mammalian Bone Marrow Chromosome Aberration Test

The mammalian in vivo chromosome aberration test is used for
the detection of structural chromosome aberrations induced by
test compounds in bone marrow cells of animals, usually rodents
(rats and mice).

Test ModelMice, Rats
Assay ControlsVehicle Control: Appropriate vehicle control
Positive Control: Cyclophosphamide monohydrate
Exposure Time24 Hours and 48 hours
Test Item QuantityTop dose concentration – Quantity may vary 2000 mg/kg – 13.2 grams
End PointBone marrow chromosomal aberrations in 200 metaphase
Data DeliveryPercentage of chromosomal aberration compared with vehicle control Mitotic Index
Timeline11 – 12 Weeks

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