HPRT Cell Gene Mutation Test

The in vitro mammalian cell gene mutation test can be used to detect
gene mutations induced by chemical substances.

Test ModelCHO K1
Assay ControlsVehicle Control: Aqueous or organic solvents
Positive Controls: Ethyl Methane sulphonate 7,12-Dimethylbenzanthracene
Exposure Time3 – 6 hours
20 – 22 hours
Test Item Quantity10 mM, 2 mg/mL or 2 μL/mL
End PointNumber of cells plated in selective and non-selective medium.
Data DeliveryRelative Survival and Mutant Frequency.
Timeline10 – 11 Weeks

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