Toxicology Services

Driven by world-class scientists and state-of-the-art accredited facilities, Syngene helps advance your compounds from screening to IND submission

Get the Latest News & Insights

In Vitro and Genetic Toxicology

Syngene has a full service genetic toxicology department to support the genotoxic potential characterization of compounds from screening to IND submission. Our scientific staff and state-of-the-art facilities provide the most current and comprehensive genetic toxicology studies as per OECD guidelines. We have been executing genetic toxicology studies since 2010 and have an able and experienced analytical and bioanalytical team, toxicologists and statisticians. In the last two years itself we have completed over 300 genetic toxicology studies for our partners. In vitro toxicology is a key aspect of the discovery and predictive phase of product development. They can increasingly provide stand-alone data for specific endpoints without in vivo confirmatory studies. Also, in vitro methods developed are more predictive of the human response and have a quicker turnaround time. They act as the crossover points between drug discovery and drug development and are widely used for screening and ranking of chemicals by studying specific target to cell and tissue. In addition to the standard genotoxicity studies such as bacterial reverse mutation, micronucleus test and chromosomal aberration, we conduct in vitro cytotoxicity assay using neutral red uptake method, which is used to screen the cytotoxic potential of compounds. Recently we have also included in vitro phototoxicity test using Balb/c 3T3 method and in vitro skin irritation using Reconstructed Human Epidermis, skin corrosion using Reconstructed human epidermis and eye irritation using Reconstructed Human Cornea-like Epithelium test method.
Bacterial Reverse Mutation Test – AMES Test

Bacterial Reverse Mutation Test – AMES Test

Bacterial reverse mutation test uses amino-acid requiring strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshitis.

More Details
Request Quote
Bacterial Reverse Mutation Test- Mini Ames

Bacterial Reverse Mutation Test- Mini Ames

Bacterial reverse mutation test uses amino-acid requiring strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshitis.

More Details
Request Quote
In Vitro Chromosomal Aberration Test

In Vitro Chromosomal Aberration Test

The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells.

More Details
Request Quote
In Vitro Micronucleus Test

In Vitro Micronucleus Test

The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of
interphase cells.

More Details
Request Quote
Mammalian Erythrocyte Micronucleus Test

Mammalian Erythrocyte Micronucleus Test

The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts,

More Details
Request Quote
Mammalian Bone Marrow Chromosome Aberration Test

Mammalian Bone Marrow Chromosome Aberration Test

The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents
(rats and mice).

More Details
Request Quote
HPRT Cell Gene Mutation Test

HPRT Cell Gene Mutation Test

The in vitro mammalian cell gene mutation test can be used to detect
gene mutations induced by chemical substances.

More Details
Request Quote
In Vitro Skin Irritation Test: Reconstructed Human Epidermis (RHE)

In Vitro Skin Irritation Test: Reconstructed Human Epidermis (RHE)

In Vitro Skin Irritation Test is used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

More Details
Request Quote
In Vitro 3T3 NRU Phototoxicity Test

In Vitro 3T3 NRU Phototoxicity Test

The in vitro 3T3 Neutral Red Uptake (NRU) phototoxicity test is used to identify the phototoxic potential of a test chemical activated by exposure to light.

More Details
Request Quote
In Vitro 3T3 NRU Cytotoxicity Test

In Vitro 3T3 NRU Cytotoxicity Test

The Neutral red uptake (NRU) cytotoxicity test is based on the ability of viable cells to incorporate and bind neutral red (NR).

More Details
Request Quote
In Vitro Skin Corrosion Test: Reconstructed Human Epidermis (RHE)

In Vitro Skin Corrosion Test: Reconstructed Human Epidermis (RHE)

In Vitro Skin Corrosion Test is used for the hazard identification of those chemicals and mixtures capable of inducing skin corrosion

More Details
Request Quote
In Vitro Eye Irritation or Serious Eye Damage Test : Reconstructed human Cornea-like Epithelium (RhCE)

In Vitro Eye Irritation or Serious Eye Damage Test : Reconstructed human Cornea-like Epithelium (RhCE)

In Vitro eye irritation is used to evaluate the eye hazard potential of a test chemical based on its ability to induce cytotoxicity in a RhCE tissue construct, as measured by the tetrazolium dye.

More Details
Request Quote

Upcoming Events

Eurotox 2020 Copenhagen, Denmark

Date: 6th- 9th Sept , 2020

American college of Toxicology JW Marriott, Austin, Texas

Date: 15th- 18th Nov , 2020